1.
Planta Med
; 57(6): 531-5, 1991 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-1818344
RESUMO
Crude methanolic extracts from both root and cell cultures of Euphorbia calyptrata were investigated and found to be active on the CNS. An active fraction was isolated from the methanolic extract of suspension cultures; this possesses significant depressant activity on the CNS. When compared with the crude methanolic root extract, this fraction showed the presence of some common products, four of which were isolated and characterized as helioscopinolides A, C, D, and E. The pure products, administered intraperitoneally to mice, showed different activities on the CNS. Helioscopinolide C showed a clear depressant activity, helioscopinolide E a mild, short depressant effect, while helioscopinolides A and D had an opposite excitatory effect.
Assuntos
Sistema Nervoso Central/efeitos dos fármacos , Diterpenos/farmacologia , Extratos Vegetais/farmacologia , Animais , Células Cultivadas , Diterpenos/isolamento & purificação , Camundongos
2.
Acta Physiol Hung
; 75 Suppl: 55-6, 1990.
Artigo
em Inglês
| MEDLINE
| ID: mdl-1973573